03122nab a2200361za 450000100060000000300050000600500170001100700030002801900070003103500240003803500180006203500240008004000220010404100080012610000280013411900090016224501230017152018930029470000290218770000290221670000250224570000270227070000280229770000270232577300700235285600900242297000240251297000340253697000340257097000220260499900170262695201170264355101CHUV20160413164142.0tu a16 a(Alexandrie)4589503 a(Saphir)45895 a(PubMed ID)15610228 aDI / Base externe aeng 949302aBochud, Murielle a2a3 aHeritability of renal function in hypertensive families of African descent in the Seychelles (Indian Ocean)h[article] aBACKGROUND. We estimated the heritability of three measures of glomerular filtration rate (GFR) in hypertensive families of African descent in the Seychelles (Indian Ocean). METHODS. Families with at least two hypertensive siblings and an average of two normotensive siblings were identified through a national hypertension register. Using the ASSOC program in SAGE (Statistical Analysis in Genetic Epidemiology), the age- and gender-adjusted narrow sense heritability of GFR was estimated by maximum likelihood assuming multivariate normality after power transformation. ASSOC can calculate the additive polygenic component of the variance of a trait from pedigree data in the presence of other familial correlations. The effects of body mass index (BMI), blood pressure, natriuresis, along with sodium to potassium ratio in urine and diabetes, were also tested as covariates. RESULTS. Inulin clearance, 24-hour creatinine clearance, and GFR based on the Cockcroft-Gault formula were available for 348 persons from 66 pedigrees. The age- and gender-adjusted correlations (+/- SE) were 0.51 (+/- 0.04) between inulin clearance and creatinine clearance, 0.53 (+/- 0.04) between inulin clearance and Cockcroft-Gault formula and 0.66 (+/- 0.03) between creatinine clearance and Cockcroft-Gault formula. The age- and gender-adjusted heritabilities (+/- SE) of GFR were 0.41 (+/- 0.10) for inulin clearance, 0.52 (+/- 0.13) for creatinine clearance, and 0.82 (+/- 0.09) for Cockcroft-Gault formula. Adjustment for BMI slightly lowered the correlations and heritabilities for all measurements whereas adjustment for blood pressure had virtually no effect. CONCLUSION. The significant heritability estimates of GFR in our sample of families of African descent confirm the familial aggregation of this trait and justify further analyses aimed at discovering genetic determinants of GFR. [Authors] 950436aElston, Robert C. 949304aMaillard, Marc P. 946800aBovet, Pascal 981098aSchild, Laurent 950437aShamlaye, Conrad 949305aBurnier, Michel tKidney Internationald2005g67, 1 (2005), 61-69iInl1q61-69v674 uhttp://dx.doi.org/10.1111/j.1523-1755.2005.00055.xzDate de consultation : 20.12.2004 917111aHypertension 920830aMedical History Taking 917130aHypertensionxgenetics 931150aSeychelles c55101d55101 0010406PUB_ARTEDITO709817660a5b5d2004-12-20oPUB-ART-EDITOr2016-04-13w2016-04-13xRéf. IUMSP: R 05/02