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Impact of biological and environmental variabilities on biological monitoring: an approach using toxicokinetic models (Record no. 54766)

000 -LEADER
fixed length control field 03969nab a2200421za 4500
001 - CONTROL NUMBER
control field 54766
003 - CONTROL NUMBER IDENTIFIER
control field CHUV
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20160413164120.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field tu
019 ## - DOCUMENT TYPE
Document type Article
035 ## - SYSTEM CONTROL NUMBER
System control number (Alexandrie)20142303
035 ## - SYSTEM CONTROL NUMBER
System control number (Saphir)82094
035 ## - SYSTEM CONTROL NUMBER
System control number (PubMed ID)20063230
040 ## - CATALOGING SOURCE
Original cataloging agency DI / Base externe
041 ## - LANGUAGE CODE
Language code of text/sound track or separate title eng
100 ## - MAIN ENTRY--PERSONAL NAME
9 (RLIN) 42411
Personal name Berthet, Aurélie
119 ## - DEPOT INSTITUTIONNEL
Dépôt institutionnel DUMSC
-- IST
245 ## - TITLE STATEMENT
Title Impact of biological and environmental variabilities on biological monitoring: an approach using toxicokinetic models
Medium [article]
520 ## - SUMMARY, ETC.
Summary, etc Biological monitoring of occupational exposure is characterized by important variability, due both to variability in the environment and to biological differences between workers. A quantitative description and understanding of this variability is important for a dependable application of biological monitoring. This work describes this variability,using a toxicokinetic model, for a large range of chemicals for which reference biological reference values exist. A toxicokinetic compartmental model describing both the parent compound and its metabolites was used. For each chemical, compartments were given physiological meaning. Models were elaborated based on physiological, physicochemical, and biochemical data when available, and on half-lives and central compartment concentrations when not available. Fourteen chemicals were studied (arsenic, cadmium, carbon monoxide, chromium, cobalt, ethylbenzene, ethyleneglycol monomethylether, fluorides, lead, mercury, methyl isobutyl ketone, penthachlorophenol, phenol, and toluene), representing 20 biological indicators. Occupational exposures were simulated using Monte Carlo techniques with realistic distributions of both individual physiological parameters and exposure conditions. Resulting biological indicator levels were then analyzed to identify the contribution of environmental and biological variability to total variability. Comparison of predicted biological indicator levels with biological exposure limits showed a high correlation with the model for 19 out of 20 indicators. Variability associated with changes in exposure levels (GSD of 1.5 and 2.0) is shown to be mainly influenced by the kinetics of the biological indicator. Thus, with regard to variability, we can conclude that, for the 14 chemicals modeled, biological monitoring would be preferable to air monitoring. For short half-lives (less than 7 hr), this is very similar to the environmental variability. However, for longer half-lives, estimated variability decreased. [Supplementary materials are available for this article. Go to the publisher's online edition of Journal of Occupational and Environmental Hygiene for the following free supplemental resource: tables detailing the CBTK models for all 14 chemicals and the symbol nomenclature that was used.] [Authors]
590 ## - LOCAL NOTE (RLIN)
Local note Correction to Impact of biological and environmental variabilities on biological monitoring: an approach using toxicokinetic to models : letters to the editor. J Occup Environ Hyg 2011, 8(5):D37-D38. http://dx.doi.org/10.1080/15459624.2011.569270
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 43987
Personal name Batz, Alice de
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 43844
Personal name Tardif, Robert
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 43843
Personal name Charest-Tardif, Ginette
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 43845
Personal name Truchon, Ginette
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 43407
Personal name Vernez, David
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 41092
Personal name Droz, Pierre-Olivier
773 ## - HOST ITEM ENTRY
Title Journal of Occupational and Environmental Hygiene
Place, publisher, and date of publication 2010
Relationship information 7, 3 (2010), 177-184
Display text In
Issue 3
-- 177-184
Volume 7
856 4# - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier http://dx.doi.org/10.1080/15459620903530052
Public note Date de consultation : 01.04.2010
970 ## - LOCAL SUBJECT ADDED ENTRY-- MESH
9 (RLIN) 4212
Term Biological Assay
970 ## - LOCAL SUBJECT ADDED ENTRY-- MESH
9 (RLIN) 11626
Term Environmental Monitoring
970 ## - LOCAL SUBJECT ADDED ENTRY-- MESH
9 (RLIN) 11632
Term Environmental Pollutants
970 ## - LOCAL SUBJECT ADDED ENTRY-- MESH
9 (RLIN) 18893
Term Kinetics
970 ## - LOCAL SUBJECT ADDED ENTRY-- MESH
9 (RLIN) 21867
Term Models, Biological
970 ## - LOCAL SUBJECT ADDED ENTRY-- MESH
9 (RLIN) 21981
Term Monte Carlo Method
970 ## - LOCAL SUBJECT ADDED ENTRY-- MESH
9 (RLIN) 23987
Term Occupational Exposure
970 ## - LOCAL SUBJECT ADDED ENTRY-- MESH
9 (RLIN) 11634
Term Environmental Pollutants
General subdivision analysis
970 ## - LOCAL SUBJECT ADDED ENTRY-- MESH
9 (RLIN) 23989
Term Occupational Exposure
General subdivision analysis
Holdings
Damaged status Price effective from Current Location Withdrawn status Date acquired Not for loan Permanent Location Full call number Lost status Date last seen
 2016-04-13IST, Institut universitaire romand de santé au travail; Bibliothèque 2016-04-13DisponibleIST, Institut universitaire romand de santé au travail; BibliothèquePUB-ART-EDITO 2016-04-13