Reddy, Micaela B.

Physiologically based pharmacokinetic modeling : science and applications / [publication] : / ed. by Micaela B. Reddy... [et al.] - Hoboken, NJ : Wiley-Interscience, 2005, cop. 2005 - XIX, 420 p. : ill. ; 24 cm

This book describes the development of physiologically-based pharmacokinetics (PBPK) modeling for toxic compounds over the past eight decades as well as the current uses of these models. It reviews PBPK model results for various classes of compounds with coverage of historical development, specific modeling challenges and current practices. Readers will also find discussions on the use of these PBPK models to support pharmacodynamic modeling for toxic responses and future directions for modeling. Part I : PBPK modeling for volatile organic compounds. Part II : PBPK model development for environmental pollutants. Part III : Pharmaceutical applications of PBPK models. Part IV : PBPK modeling approaches for special applications.